Similar to other genetical genomics studies, we found that many changes in transcript abundance induced by acute ethanol were linked to a relatively small number of highly influential loci, so-called ‘regulatory hotspots’ or trans-bands. This was particularly salient for eQTL profiles of the major ErGeNs (Figure 5). These networks could largely be partitioned into 6 trans-bands that mapped to loci on Chr 4, 7, 11, 13, 15 and 19. In most cases, these trans-bands were unique to specific networks, the exceptions being the Chr 7 and Chr 11 trans-bands, which were composed of genes from ErGeN1 & ErGeN3, and ErGeN3 & ErGeN10, respectively (Table 2).
