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Chunk #22 — Results and Discussion — Gene expression differences between isolation methods are associated with cellular composition and B-cell manipulation

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Variability of gene expression profiles in human blood and lymphoblastoid cell lines.
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groups was correlated with lymphocytes (ρ = 0.36, p = 1.3*10-7) whereas the two other groups of up-regulated genes were significantly positively correlated with neutrophil count (ρ = 0.20, p = 1.3*10-14; ρ = 0.50, p = 4.1*10-11). Three groups of probes were up-regulated in PAX containing probes targeting "hemoglobin" and "signal transduction" genes and the latter was significantly positively correlated with erythrocyte count (ρ = 0.25, p = 2.5*10-6) and mean cell volume (ρ = 0.25, p = 8.3*10-5) (Figure 7).