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Chunk #7 — Results

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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
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Conversely, for smoking phenotypes, significant correlations were only observed for the AN without binge-eating subtype. Smoking initiation (rg=−0.21, SE=0.06, q=0.0006), current smoking (referred to as smoking cessation in Liu et al., 2019)1 (rg=−0.19, SE=0.08, q=0.03), and cigarettes per day (rg=−0.23, SE=0.07, q=0.003) were significantly and negatively associated with AN without binge-eating. Although the correlation between ND and AN without binge-eating was in the same direction as the other smoking phenotypes, it was not significant (rg=−0.22, SE=0.12, q=0.14). The rgs comparing AN diagnosis and AN without binge-eating with each of the three non-diagnostic smoking traits all differed significantly from each other (z-scores ranged from −3.22 to −2.11; p-values<0.04).