Second, the significant rg between AN and cannabis initiation was 0.23 (SE=0.04, q<0.0001), and the significant rg between AN with binge-eating and cannabis initiation was 0.27 (SE=0.08, q=0.0017), indicating that genetic factors that increase the risk for AN also increase the risk for cannabis initiation. However, cannabis initiation was not significantly correlated with the BN factor (rg=0.15, SE=0.18, q=0.57) or with AN without binge-eating (rg=0.10, SE=0.08, q=0.31). No significant associations were observed between any eating disorder phenotype and CUD (rgs=−0.08–0.23; SEs=0.01; qs<0.57). Post-hoc analyses revealed significant differences in the rgs for AN and cannabis initiation versus AN and CUD (z-score=2.70, p=0.01). However, the rg between AN with binge-eating and cannabis initiation, while significant, was statistically different from the rg between AN with binge-eating and CUD.
