Significant positive rgs were observed for alcohol use- and cannabis use-related phenotypes. First, the rg was significiant between AN and AUD (rg=0.18; SE=0.05; q=0.0006), but not between AN and drinks per week (rg=0.01; SE=0.03; q=0.91), suggesting that genetic factors that increase risk for AN also increase risk for AUD, but little evidence exists for shared risk between AN and typical alcohol consumption. These two correlations significantly differed from each other (z-score=3.51, p=0.0005). Intriguingly, there was a significant difference in rgs for AN and AUD versus AN without binge-eating and AUD (z-score=2.28, p=0.02), but not for AN and AUD versus AN with binge-eating and AUD (z-score=0.23, p=0.82). No significant association between the BN factor, which included items pertaining to both binge eating and compensatory behaviors, and either alcohol use-related phenotype was observed.
