The overall SNP-based heritability for the eating disorder phenotypes ranged from 0.1992 to 0.3911, whereas the corresponding heritabilities for the substance use-related phenotypes ranged from 0.0273 to 0.3548 (Supplemental Table 1). Figure 1 and Supplemental Table 1 show the rgs between all four eating disorder phenotypes and eight substance use-related phenotypes. Broadly speaking, there were significant rgs across substance use-related phenotypes, ranging from 0.21 (AUD and cigarettes per day) to 0.70 (drinks per week and AUD). Cannabis initiation was not significantly genetically correlated with cigarettes per day or ND. For the remainder of the results, we focus on previously unexplored associations of interest in this study—correlations between eating disorder and substance use-related phenotypes. For these associations, the genetic covariance intercepts ranged from −0.0252 (standard error [SE]=0.007; AN and cannabis initiation) to 0.0113 (SE=0.0072; AN and CUD), indicating some sample overlap (or low-level confounding) existed (Yengo et al., 2018), although the LDSC approach parses this overlap from the rg estimation.
