When entering the study, probands were evaluated for low LR using oral alcohol challenges that resulted in average BACs of 60 mg/dL at 60 minutes.24,34 Probands then were followed over the next 40 years with personal interviews about every 5 years regarding changes in demography, substance use and problems, as well as major psychiatric disorders. These interviews used questions derived from the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) instrument, which has validity, retest reliabilities, and cross-interviewer reliabilities of .7 to .8.35,36 Over the years, as probands themselves became parents, information about their children’s early development was gathered from the probands and the offspring’s mothers, and the same interviews used for the probands were also used with their children when they reached age 18 and older.
