CDON (rs4937076) is involved in muscle cell differentiation and cell adhesion. This gene is part of a cell-surface receptor complex that mediates cell–cell interactions (31). Cell adhesion molecules have been implicated in several processes, including cell migration, growth control and tumour genesis. Cole and Krauss (32) generated mice lacking CDON, 60% of which failed to survive beyond weaning at postpartum day 21. CDON−/− mice displayed the hallmark facial defects associated with microforms of holoprosencephaly, including lack of or solitary central maxillary incisors.
