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Chunk #12 — MATERIALS AND METHODS — Statistical Analysis — Association Analysis of Previously Reported SNPs

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Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
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To determine whether the 12 SNPs previously-reported as genome-wide significant in GWAS for alcohol consumption-related traits (e.g. MaxDrinks) were associated with alcohol consumption in the current study, we used a nominal significance level of 0.05. A more stringent multiple testing correction accounting for the 2 phenotypes tested and for the number of variants tested for each ethnic group is also presented (Bonferroni-corrected alpha level of 0.05/(2×6) for European population, of 0.05/(2×4) for Asian population, and of 0.05/(2×2) for African ancestry population).