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Chunk #11 — MATERIALS AND METHODS — Statistical Analysis — Trans-Ethnic Meta-Analysis

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Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
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For the combined meta-analysis of the two alcohol consumption phenotypes across the 4 race/ethnicity groups, fixed effects and random effects summary estimates were calculated for an additive model using R package “meta”. Heterogeneity index, I2 (0–100%) as well as P-value for Cochrane’s Q statistic were assessed among groups. We report fixed effects results, except when there was significant heterogeneity between race/ethnicity groups, in which case we report values for a random effects model.