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Chunk #0 — Introduction

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Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation.
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GABAergic neurons are a diverse population with crucial processing roles (Tremblay et al., 2016). These cells have been implicated in human disorders, including autism, schizophrenia and epilepsy (Marin, 2012). Mammalian inhibitory interneurons originate from the embryonic ganglionic eminences, with the majority produced in the medial ganglionic eminence (MGE) (Bandler et al., 2016). These cells either migrate tangentially to the pallium and integrate into the cortical circuitry, or remain in the ventral telencephalon and become striatal interneurons (Marin et al., 2000). MGE-derived cortical interneurons differentiate into either Parvalbumin (PVALB) or Somatostatin (SST)-expressing cells (Butt et al., 2005; Cobos et al., 2006; Xu et al., 2004).