We performed replication analysis in 1,342,778 independent samples provided by 23andMe, including 455,350 depression cases. 211 variants were available for testing in the 23andMe sample. Of these 211, 2 variants had discordant effect direction (0.9%) but not significantly so (p >= 0.28), 209 variants had concordant effect directions (99.1%), 192 showed at least nominal significance p<0.05 (91%), 144 remained significant after Bonferroni correction for multiple comparisons p<0.05/211=2.37×10–04 (68%), and 81 were genome-wide significant p<5×10–08 (38%). These results are reported in Table S1.
