MDD in African Americans, so we examined overlap with the 223 GWS SNPs from our primary MDD-META meta-analysis of European American ancestry. Of the 223 GWS SNPs from the primary analysis, 206 were available following QC in the AA cohort. 61% (n=125) of the EUR GWS SNPs had the same direction of effect in AAs, with 20 nominally significant (p<0.05) and 1 surviving Bonferroni correction. Finally, we conducted a transancestral meta-analysis of results from the primary GWAS of European and African ancestry. This transancestral analysis of 366,434 cases and 847,433 controls identified 233 independent significant SNPs at 183 genomic risk loci.
