LD patterns at the COMT locus in EA and AA individuals from the family-based set of subjects were analyzed by HAPLOVIEW version 3.2 (Barrett et al., 2005). Tests of single SNP association with CIP were performed using FBAT (Family-Based Association Tests) (Horvath et al., 2001). HBAT (Haplotype-Based Association Tests) (Horvath et al., 2004) was used for haplotype analysis by focusing on SNPs that yielded a p-value ≤0.05 in single-SNP analyses in each population. We ran SNPSpD using all family members and the approach of Li and Ji (Li and Ji, 2005) to ensure an experiment-wide significance threshold of 5% to control type I error.
