COGA includes EEG-derived event-related oscillation (ERO) response measures.24 Prior studies have found the P300 component during the standard visual oddball paradigm to be associated with family history of AUD.24 Subgroup differences for parietal delta (1-3 Hz) and frontal theta (3-7 Hz) band EROs (300-700 millisecond window) and parietal P300 amplitude were also included as correlates of AUD severity in cross-sectional analyses. Polygenic scores (PGS) for AUD diagnostic status (ie, case/control), derived from a meta-analysis of large-scale genome-wide association study summary statistics,25,26,27,28 were calculated for genotyped individuals of European (n = 5396) and African American (n = 1774) ancestry separately using PRS-CS-auto29 and PRS-CSx,30 respectively (eMethods in Supplement 1).
