To further evaluate cell-type enrichment, we intersected the GWAS results with two recent epigenomic maps of cell-specific open chromatin58,59 using an LD score partitioned heritability approach60. Again, we observed a clear contrast between the enrichments in the brain and non-brain tissue (Figure 3B). Consistent with our FUMA-based results and prior reports12,14, the strongest enrichments were measured for neuronal cell types, phenotypically manifested by severe synaptic loss and deficits in functional connectivity61,62. Conversely, the enrichments of genetic depression risk in astrocytes and oligodendrocyte lineages have not been reported previously, albeit having support in behavioral and postmortem studies63-65.
