We next tested whether the GWAS results were enriched with respect to the transcriptomic profiles of human tissues. At the specific tissue level, we found significant enrichment exclusively in brain tissues, including all the brain tissues analyzed (Bonferroni corrected P-value threshold P=0.00093, with P-values ranging from P=1.17x10−4 to P=8.36x10−13 for the brain tissues, Supplementary Figure S12). Cell-type enrichment analyses revealed experiment-wide significant association (across all 13 datasets tested) of primarily neuronal cell-types, including dopaminergic and GABAergic neurons (P-values ranging from P=1.3x10−4 to P=5.8x10−11 for the significant associations after Bonferroni correction P= 1.87x10−4, Figure 3A and Supplementary Figure S13). Both GABAergic neurons and oligodendrocyte progenitor cells of the human prefrontal cortex were already enriched at prenatal stages.
