Chunk #7 — Materials and Methods — Subjects, genotyping and assignment of nominal significance of dependent vs control allele frequencies in each sample — 1) dbGAP samples from the FSCD, COGA and COGEND studies

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Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.

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dependence on alcohol. Controls, defined in dbGap variable phv00022939.v1.p1.c2 “final_type”, displayed no DSM dependence on alcohol, cocaine, marijuana, opioids or other drugs but may have evinced DSM nicotine dependence, FTND scores >4 and/or regular smoking as defined by smoking >100 cigarettes in their lives. We identified 1171 dependent and 1395 control unrelated European-American subjects and 652 dependent and 499 control unrelated African-American subjects for this analysis. Subjects were 45% male; 48% of the alcohol-dependent subjects were also dependent on cocaine.