Chunk #55 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Genotyping: We assessed allele frequencies for methamphetamine-dependent and control subjects in DNA pools, each containing equal amounts of DNA from 20 individuals of the same phenotype group, on four sets of arrays, two arrays from “100k” and two from “500k” Affymetrix sets (Sample 5) or two arrays from “500k” Affymetrix sets (Sample 4).