The variants selected by elastic net were used to calculate the genetically determined component of Ψ, i.e., \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hat \Psi$$\end{document}Ψ^,\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{{\hat{\mathrm \Psi }}}} = \alpha + \mathop {\sum }\limits_{k = 1}^N \beta _kX_k + \varepsilon$$\end{document}Ψ^=α+∑k=1NβkXk+εwhere α is the intercept (basal level), βk is the coefficient (weight or effect size) of SNV k with alternative allele dosage Xk, ε is the noise, and N ≤ 20.
