paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #8 — Materials and methods — Modeling PSI using genotype

Source
RNA alternative splicing impacts the risk for alcohol use disorder.
Embedded
yes

Text

probability that the SNVs included in each model were informative and to reduce the computation complexity for events with large numbers of SNVs in the transcribed region, we selected up to 20 top SNVs based on the ranking of their genotype correlation with Ψ. Next, we used the elastic net regularization algorithm to determine which variants were predictive for each splicing event.