intercept was 1.021 (se=0.010), and the attenuation ratio of 0.053 (se=0.027) was non-significant, indicating that the observed genomic inflation is indicative of polygenicity rather than stratification or cryptic population structure 25. The LD-score regression SNP-heritability estimates for BD were 0.17-0.23 on the liability scale assuming population prevalence of 0.5-2%. See Supplementary Table 1A, Online Methods and Supplementary Note for sample and method details.
