Members of the broader scientific community are using TOPMed resources through the WGS and phenotype data available on dbGaP, the BRAVO variant server and the imputation reference panel on the TOPMed imputation server. Full utilization of the programme’s resources by the scientific community will require new approaches for dealing with the large size of the omics data, the diversity of the phenotypic data types and structures, and the need to share data in a manner that supports the privacy and consent preferences of participants. These issues are currently being addressed in partnership with the NHLBI BioData Catalyst75 cloud-computing programme.
