Consistent with the GTT data, similar effects with rmuFG21 were observed on insulin levels in the different groups of mice (Figure 4I). Recombinant muFGF21 reduced insulin levels in WT sham mice, but not Tg sham mice (Figure 4I; post-treatment), whereas it lowered insulin levels in Tg–tx mice (of note, this effect was only statistically significant when comparing the same mice to their pre-treatment insulin levels). Interestingly, we observed low plasma levels of adiponectin in Tg mice (Figure 4J), and transplantation did not alter these levels, however we observed an increase in rmuFGF21 treated WT mice and also Tg–tx mice only (no effect in Tg-sham mice) further supporting the beneficial effects of WAT transplantation and rmuFGF21 treatment.
