Recombinant muFGF21 lowered circulating cholesterol levels in WT and Tg sham mice (Figure 4K). Recombinant muFGF21 exhibited a minimal reduction in cholesterol levels of Tg–tx mice (Figure 4K), possibly due to the extent of the direct effects of transplanting adipose tissue alone. Plasma triglycerides levels were also lowered in Tg–tx mice in response to adipose tissue transplantation alone (Figure 4L). In WT mice, rmuFGF21 lowered triglycerides levels as expected, whereas triglycerides were neither reduced in Tg sham nor Tg–tx mice administered rmuFGF21.
