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Chunk #28 — Results — Adipose Transplantation in Lipodystrophy Mice Restores FGF21 Responsiveness

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FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.
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Liver weights were decreased by transplantation (Figure S5D) yet rmuFGF21 was effective in lowering liver weights only in Tg-sham mice. BAT weight was not affected by either transplantation or rmuFGF21 treatment in either WT or Tg mice (Figure S5E). Only WT adipose tissue weights were decreased in response to rmuFGF21, and transplantation in Tg mice had no effect on BAT and WAT (Figure S5E–F).