Next, we analyzed the cellular composition in PLD3 carriers (n = 33). PLD3 carriers exhibited significantly lower relative proportion of neurons compared to controls (β = − 0.10; p = 1.60 × 10−04; Fig. 3d) and a significant higher relative proportion of astrocytes (β = 0.13; p = 2.84 × 10−03; Table 4; Fig. 3d). Sporadic AD non-carrier cases also exhibited significantly lower relative proportion of neurons compared to controls (β = − 0.11; p = 5.45 × 10−03) and significant higher relative proportion of astrocytes (β = 0.13; p = 2.95 × 10−04; Table 4; Fig. 3d). The cell proportion between sporadic AD non-carriers and PLD3 carriers did not show any significant difference (p > 0.05).
