Chunk #63 — Results — Specific genetic variants confer a distinctive cell composition profile

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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corrected6420.051.3 × 10−02− 0.052.7 × 10−02− 1.82 × 10−038.13 × 10−01− 2.66 × 10−031.28 × 10−01 Mean plaque counts corrected6730.052 × 10−02− 0.051.59 × 10−021.73 × 10−038.15 × 10−01− 2.2 × 10−031.5 × 10−01 APOEε4 counts all samples556− 0.042.6 × 10−030.051.31 × 10−03− 0.014.47 × 10−02−3.58 × 10−046.53 × 10−01 APOEε4 counts AD cases225− 0.034.01 × 10−020.034.23 × 10−02− 4.52 × 10−033.73 × 10−01− 5.13 × 10−046.78 × 10−01 CDR corrected225− 0.032.02 × 10−020.032.03 × 10−02− 4.86 × 10−033.19 × 10−01− 4.91 × 10−046.93 × 10−01 Braak corrected198− 0.037.35 × 10−020.044.89 × 10−02− 0.018.54 × 10−02−1.08 × 10−034.12 × 10−01AD Alzheimer’s disease, ADAD autosomal dominant AD, LOAD late-onset AD, CDR Clinical Dementia Rating