Chunk #62 — Results — Specific genetic variants confer a distinctive cell composition profile

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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vs Control45− 0.115.45 × 10−030.132.95 × 10−04− 0.024.55 × 10−01− 3.48 × 10−031.13 × 10−01 APOEε4+ vs APOEε4- LOAD cases & controls100− 0.062.11 × 10−020.055.35 × 10−020.013.72 × 10−01− 8.09 × 10−046.31 × 10−01 APOEε4+ vs APOEε4- LOAD cases only84− 0.062.69 × 10−020.032 × 10−010.031.4 × 10−02− 8.31 × 10−046.21 × 10−01 CDR corrected84− 0.062.78 × 10−020.032.05 × 10−010.031.16 × 10−02−1.05 × 10−035.37 × 10−01 Braak corrected73− 0.063.66 × 10−020.033.72 × 10−010.034.51 × 10−03− 1.14 × 10−035.93 × 10−01Mount Sinai Brain Bank - Multi-region AD TREM2 carriers vs Control301− 0.033.57 × 10−010.033.19 × 10−01− 2.08 × 10−037.87 × 10−01− 2.68 × 10−038.67 × 10−02 AD non-carriers TREM2 vs Control882− 0.071.91 × 10−080.081.25 × 10−08− 3.36 × 10−034.79 × 10−01− 2.89 × 10−047.97 × 10−01 AD TREM2 vs AD non-TREM26730.051.98 × 10−02− 0.051.58 × 10−022.12 × 10−037.76 × 10−01− 2.13 × 10−031.74 × 10−01 CDR corrected6730.045.83 × 10−02− 0.044.46 × 10−021.68 × 10−038.19 × 10−01− 1.92 × 10−032.22 × 10−01 Braak corrected6420.051.3 × 10−02− 0.052.7 × 10−02− 1.82 × 10−038.13 × 10−01− 2.66 × 10−031.28 × 10−01 Mean plaque counts corrected6730.052 × 10−02− 0.051.59 × 10−021.73 × 10−038.15 × 10−01− 2.2 × 10−031.5 × 10−01 APOEε4 counts all samples556− 0.042.6 ×