Additionally, FH has also been associated with aberrant electrophysiological characteristics such as low P3/P300 (an event-related brain potential; ERP) amplitude in response to target stimuli, often considered as a biomarker of vulnerability for AUD (Begleiter et al., 1984, 1987; Hill et al., 1990; Porjesz et al., 2005; Hill et al., 2009; Cservenka, 2016). Indeed, several studies have demonstrated that low P3 amplitude appears to be independent of disease state and varies in individuals with a FH of AUD compared to controls from non-AUD families (Porjesz et al., 1998; Euser et al., 2012; Hill and O’Brien, 2015).
