interest is the study by Onori et al. (2010) examining alcohol use disorders; no significant associations were found with rs567926, rs279871, rs279858, or rs279845. Finally, Lind et al. (2008) found evidence for association with rs279858 with quantitative sum alcohol dependence symptoms, as well as a single principal component factor score from the DSMIV alcohol dependence symptoms. However, the direction of effect was opposite from that previously observed and replicated (Edenberg et al. 2004; Covault et al. 2004; Lappalainen et al. 2005; Fehr et al. 2006; Bierut et al. 2010; Villafuerte et al. 2011; Li et al. 2013) and furthermore did not survive correction for multiple testing. Thus the overall results for association of this region with alcohol disorders remain mixed.
