moderate to high anticardiolipin antibodies (aCL IgG>40) as well as a subset of APS patients who also were aCL positive (see above). This effect was not detected in patients with low titer aCL or presence of only lupus anticoagulant. ACL antibodies can be found in patients with a wide spectrum of clinical conditions however the higher titers of these antibodies are more commonly seen in APS. To our knowledge the potential association of this SNP among patients with primary or secondary APS has not been reported previously. A recent study in a Polish population with endometriosis, only those with positive anti-cardiolipin antibodies and anti-nuclear antibodies were associated with rs2476601 (P = 0.009). However, the number of samples was small and it is not clear whether any of these patients suffered from co-existent APS [62]. It has been reported in multiple lupus studies [63], [64] that the presence of aCL (IgG) antibodies in lupus patients especially those with APS syndrome, are associated with poor prognosis, increased mortality, and an earlier time of onset of several criteria, in particular malar rash and nephritis. This could be related to thrombotic events in kidney, vasculitis, arterial occlusions and coexistent thrombocytopenia. Given the notable increase
