MAGMA gene-tissue analysis of 54 tissue types showed PTSD gene enrichment in the brain (most notably in cerebellum, but also cortex, hypothalamus, hippocampus and amygdala) and in the pituitary, with enrichment found across all 13 examined brain regions (Extended Data Fig. 4). Cell type analysis conducted in midbrain tissue data34 identified GABAergic neurons, GABA neuroblasts, and mediolateral neuroblast type 5 cell types as having enriched associations above other brain cell types tested (P < 0.05/268) (Extended Data Fig. 5). GABAergic neurons remained significant (P = 4.4 × 10−5) after stepwise conditional analysis of other significant cell types.
