Chunk #15 — Results — Gene-based, gene-set, and gene-tissue analyses

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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MAGMA gene-set analysis of 15,483 pathways and gene ontology (GO) terms from MSigDB33 identified 12 significant GO terms. Significant terms were related to the development and differentiation of neurons (e.g. go_central_nervous_system_development, P = 2.0 × 10−7), the synaptic membrane (e.g. go_postsynaptic_membrane, P = 6.9 × 10−7), gene regulation (go_positive_regulation_of_gene_expression, P = 1.0 × 10−6), and nucleic acid binding (P = 1.52 × 10−6) (Extended Data Fig. 3 and Supplementary Table 15).