For biological annotation, we focus on the results from the autosomal meta-analysis of EduYears. Across an extensive set of analyses (see Supplementary Figure 7 for a flowchart), all major conclusions from the largest previous GWAS of EduYears10 continue to hold but are statistically stronger. For example, we applied the bioinformatics tool DEPICT19 and found that, relative to other genes, genes near our lead SNPs are overwhelmingly enriched for expression in the central nervous system (Fig. 3A, Supplementary Table 6).
