The UKB v2 genotypes were genotyped on the UKB Axiom array, and imputed to the Haplotype Reference Consortium (HRC) by the UKB;29 SNPs on the UK10K/1000Genomes panel were excluded from the current analysis. Imputed genotypes were converted to PLINK hard calls. For the initial GRS analysis, we considered genotyped or HRC-imputed SNPs with imputation INFO > 0.01 and global MAF > 0.001 (14.5 M autosomal SNPs). A further QC step was performed on the final metaGRS (see below).
