Chunk #36 — DISCUSSION AND CONCLUSIONS

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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This study contributes several new findings about genetic risk for nicotine dependence. The CHRNA5-CHRNA3-CHRNB4 region clearly plays a role in nicotine dependence risk not only in European-Americans but also in African-Americans, and our evidence suggests that multiple variants are involved.