Chunk #35 — RESULTS — Multilocus analyses — rs578776 and rs16969968

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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To explore this question in EAs, we tested for association of rs578776 after controlling for rs16969968 (coded additively). Rs578776 remains significant (p-value 0.0055, OR = 0.80 (0.68–0.94)). We also tested for the effect of one locus in homozygotes of the other. Because |D′| is high, this test can be carried out in only the “GG” genotype at rs16969968 or the “CC” genotype at rs578776. In both cases, the second SNP remains significant in EAs. Among “GGs” at rs16969968, rs578776 has p = 0.018, OR = 0.79 (0.65–0.96)); among “CCs” at rs578776, rs16969968 has p = 0.0039, OR = 1.29 (1.09–1.54)).