Chunk #34 — RESULTS — Multilocus analyses — rs578776 and rs16969968

Source

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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Both rs16969968 and rs578776 show strong association with nicotine dependence in European-descent populations. There is debate about whether these associations are independent or whether they reflect a single finding.