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Chunk #33 — RESULTS — Multilocus analyses — rs555018 and rs16969968

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
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We also tested each SNP within the one available homozygous genotype group of the other. The test cannot be performed in the second homozygous group because there is essentially only one genotype present at the other locus (|D′|>0.99; see also Table 4). In AAs, rs555018 remains significant (p= 0.046, OR = 0.78 (0.61–1.00)) when tested within the 622 “GG” homozygotes at rs16969968; within the 350 rs555018 “TT” homozygotes, rs16969968 has p = 0.22, OR = 1.51 (0.78–2.94). In EAs, rs555018 has p = 0.12 (OR= 1.17 (0.96–1.44)) in the 871 rs16969968 “GGs”, and rs16969968 has p = 2.08 × 10−6, OR = 1.73 (1.38–2.17) in the 683 rs555018 “TTs”.