Chunk #32 — RESULTS — Multilocus analyses — rs555018 and rs16969968

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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This contrast in the direction of effect is clarified by joint analyses of rs16969968 with rs555018, using the genotype that is homozygous for both major alleles as the reference (Table 4). In the presence of “GG” at rs16969968, having 1 or two copies of the minor “C” allele at rs555018 increases risk in EAs, but confers protection in AAs (Table 4, top row in each panel). For rs16969968, we see a consistent direction of effect of the “A” risk allele in EAs and AAs, regardless of genotype at rs555018.