Chunk #31 — RESULTS — Multilocus analyses — rs555018 and rs16969968

Source

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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First, we tested rs555018 in EAs after controlling for rs16969968 (coded additively) as a covariate in the logistic regression. The goal was to determine if rs555018, which shows no main-effect association in EAs, might be associated after adjusting for rs16969968. After accounting for rs16969968, rs555018 has p-value 0.044, OR = 1.18 (1.01–1.39); rs588765 has p-value 0.038, OR = 1.19 (1.01–1.40). The odds ratios in EAs at these the expression-associated SNPs have opposite direction to those in AAs.