The 2006 wave of the Social Environment and Biomarkers of Aging Study (SEBAS) comprised a nationally representative sample of Taiwanese aged 53 and older. Written informed consent was obtained for participation in both the in-home interview and hospital visit, which entailed a medical examination. The research was approved by human subjects committees in Taiwan and at Georgetown University and Princeton University. In-home interviews were completed with 1,284 respondents, including 757 participants aged 60 and over who participated in the medical examination in the 2000 SEBAS (89.5% response rate) as well as 527 respondents from a younger cohort aged 53 to 60 (80.2% response rate).