The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms.
paper
Cited
Public
- Authors
- Goldman, Noreen; Glei, Dana A; Lin, Yu-Hsuan; Weinstein, Maxine
- Year
- 2010
- Journal
- Depression and anxiety
- PMID
- 20196101
- DOI
- 10.1002/da.20660
- PMCID
- PMC2841212
BACKGROUND: We compare the genotype distribution for the serotonin transporter polymorphism (5-HTTLPR) in a sample of older Taiwanese adults with samples of various racial and ethnic groups collected in other studies. We also explore interactions among sex, stressors, and 5-HTTLPR genotype on depressive symptoms in our sample. METHODS: Using a nationally representative sample of 984 Taiwanese aged 53 and older, we model depressive symptoms as a function of 5-HTTLPR genotype and two classes of stressors: lifetime trauma and recent major life events. We test two- and three-way interactions among stressors, 5-HTTLPR, and sex. RESULTS: This sample exhibits higher frequency of S/S and lower frequency of L/L genotype than Western samples, but the distribution is comparable to those in East Asian populations. Nearly 9% carry an allele (XL) that has rarely been reported in the literature. Although the gene-environment (GxE) interaction with recent major life events is not significant, our results suggest that trauma has a worse effect on depressive symptoms for those with S/S or S/L genotype than for those who do not carry the S allele (P<0.05). We find no evidence that this GxE interaction varies by sex. CONCLUSIONS: Previous studies of this GxE interaction have been inconclusive, perhaps because interactions between genotype and stressful events are more prominent under extreme stressors. Our findings underscore the need to move beyond a bi-allelic parameterization of the 5-HTTLPR polymorphism and raise questions about why East Asian populations exhibit low rates of depression despite a high frequency of the S allele.
No figures extracted from this document.
1β20 of 31
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Dynamic Model of Serotonin Presynapse and Its Application to Suicide Attempt in Patients with Bipolar Disorder. | RadenkoviΔ L et al. | β | 2025 | β |
| Fibromyalgia: are you a genetic/environmental disease? | Ablin JN | β | 2025 | β |
| Interleukin-1Ξ² rs16944 and rs1143627 polymorphisms and risk of developing major depressive disorder: A case-control study among Bangladeshi population. | Toma FM et al. | β | 2025 | β |
| Molecular Effect of Variants in Serotonin Transporter Gene in Women with Alcohol Use Disorder. | Rychel M et al. | β | 2025 | β |
| Racial and Ethnic Considerations for the Clinical Practice of Psychopharmacology and Research Methodology: A Narrative Review of the Growing Body of Literature. | Olagunju AT et al. | β | 2025 | β |
| Sex differences in the network structures of depressive symptom profiles in Asian patients with depressive disorders: findings from the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3. | Kim HS et al. | β | 2025 | β |
| Association between the Taq1A polymorphism and problematic media use in preadolescent children. | Emond JA et al. | β | 2024 | β |
| Connection Failure: Differences in White Matter Microstructure Are Associated with <i>5-HTTLPR</i> but Not with Risk Seeking for Losses. | Neukam PT et al. | β | 2024 | β |
| The role of serotonin in depression-A historical roundup and future directions. | Bremshey S et al. | β | 2024 | β |
| Biological Features of the Outcome-Based Intrinsic Capacity Composite Scores From a Population-Based Cohort Study: Pas de Deux of Biological and Functional Aging. | Meng LC et al. | β | 2022 | β |
| Effects and Mechanisms of Acupuncture on Diarrhea-Predominant Irritable Bowel Syndrome: A Systematic Review. | Zhang G et al. | β | 2022 | β |
| Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices. | MartΓnez RM et al. | β | 2022 | β |
| The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome. | Zhao T et al. | β | 2022 | β |
| The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder. | Chen X et al. | β | 2022 | β |
| 5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression. | Jang YJ et al. | β | 2021 | β |
| A Load to Find Clinically Useful Biomarkers for Depression. | Nikolac Perkovic M et al. | β | 2021 | β |
| Association of COMT, BDNF and 5-HTT functional polymorphisms with personality characteristics. | Tommasi M et al. | β | 2021 | β |
| Connection Failure: Differences in White Matter Microstructure are associated with<i>5-HTTLPR</i>but not with Risk-Seeking for Losses | Neukam PT et al. | β | 2021 | β |
| Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study. | Liu HY et al. | β | 2021 | β |
| Effects of Polymorphisms in the Serotonin Transporter Promoter-Linked Polymorphic Region on Postthoracotomy Pain Severity. | Kimura A et al. | β | 2021 | β |
| Late Life Depression: The Essentials and the Essential Distinctions. | Husain-Krautter S et al. | β | 2021 | β |
| The impact of COMT, BDNF and 5-HTT brain-genes on the development of anorexia nervosa: a systematic review. | Abou Al Hassan S et al. | β | 2021 | β |
| The Mediating Effect of Psychological Distress on the Association between BDNF, 5-HTTLPR, and Tinnitus Severity. | Jeong JE et al. | β | 2021 | β |
| An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices. | Chen C et al. | β | 2020 | β |
| Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder. | Shao X et al. | β | 2020 | β |
| Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation. | Widom CS et al. | β | 2020 | β |
| Gender Differences in Depression: Evidence From Genetics. | Zhao L et al. | β | 2020 | β |
| The Multifaceted Effects of Serotonin Transporter Polymorphism (5-HTTLPR) on Anxiety, Implicit Moral Attitudes, and Harmful Behaviors. | MartΓnez RM et al. | β | 2020 | β |
| Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis. | Rao S et al. | β | 2019 | β |
| <i>SLC6A4</i> Repeat and Single-Nucleotide Polymorphisms Are Associated With Depression and Rest Tremor in Parkinson's Disease: An Exploratory Study. | Wang JY et al. | β | 2019 | β |
| Maladaptive Coping Strategies and Neuroticism Mediate the Relationship Between 5HTT-LPR Polymorphisms and Symptoms of Anxiety in Elite Athletes. | Altamura M et al. | β | 2019 | β |
| Pharmacogenetics of alcohol use disorder treatments: an update. | Hartwell EE et al. | β | 2019 | β |
| Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression. | Williams MS et al. | β | 2019 | β |
| Predicting Behavior Problems in Korean Preschoolers: Interactions of the <i>SLC6A4</i> Gene and Maternal Negative Affectivity. | Ha J et al. | β | 2019 | β |
| rs2572431 Polymorphism on Chromosome 8 Is Associated With Individual Differences in Anxiety Related Coping Modes. | Jung S et al. | β | 2019 | β |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | β | 2018 | β |
| Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging. | Zannas AS | β | 2018 | β |
| Genetic influence alters the brain synchronism in perception and timing. | Marinho V et al. | β | 2018 | β |
| Insights and barriers to clinical use of serotonin transporter pharmacogenetics in antidepressant therapy. | Stevenson JM | β | 2018 | β |
| The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder. | Han KM et al. | β | 2018 | β |
| Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda. | Kalungi A et al. | β | 2017 | β |
| Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | Yeo SH et al. | β | 2017 | β |
| Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity? | Dalle Molle R et al. | β | 2017 | β |
| Interaction effect between 5-HTTLPR and HTR1A rs6295 polymorphisms on the frontoparietal network. | Long H et al. | β | 2017 | β |
| Letter to the Editor: Bias in the measurement of bias. Letter regarding 'Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression'. | Vrshek-Schallhorn S et al. | β | 2017 | β |
| Systematic review and meta-analysis of genetic studies of late-life depression. | Tsang RS et al. | β | 2017 | β |
| The Serotonin Transporter and Early Life Stress: Translational Perspectives. | Houwing DJ et al. | β | 2017 | β |
| The serotonin transporter gene 5-HTTLPR polymorphism is associated with affective psychoses but not with schizophrenia: A large-scale study in the Russian population. | Golimbet V et al. | β | 2017 | β |
| The triallelic serotonin transporter gene polymorphism is associated with depressive symptoms in adults with chronic pain. | Hooten WM et al. | β | 2017 | β |
| 5-HTTLPR and gender differences in affective disorders: A systematic review. | Gressier F et al. | β | 2016 | β |
| Association Study and Meta-Analysis of Polymorphisms, Methylation Profiles, and Peripheral mRNA Expression of the Serotonin Transporter Gene in Patients with Alzheimer's Disease. | Yamazaki K et al. | β | 2016 | β |
| Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. | Arpawong TE et al. | β | 2016 | β |
| In my end is my beginning: developmental trajectories of adverse childhood experiences to late-life suicide. | Sachs-Ericsson NJ et al. | β | 2016 | β |
| Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span. | Turan B et al. | β | 2016 | β |
| Psychosocial mechanisms of serotonin transporter's genetic polymorphism in susceptibility to major depressive disorder: mediated by trait coping styles and interacted with life events. | Wang Y et al. | β | 2016 | β |
| Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin Transporter Gene Expression: a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants. | Iurescia S et al. | β | 2016 | β |
| Advances in biomarkers of major depressive disorder. | Huang TL et al. | β | 2015 | β |
| Association Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder. | Park SY et al. | β | 2015 | β |
| Genetic association analysis of serotonin transporter polymorphism (5-HTTLPR) with type 2 diabetes patients of Pakistani population. | Hameed A et al. | β | 2015 | β |
| Genetic Variations in the Serotonergic System Mediate a Combined, Weakened Response to SSRI Treatment: A Proposed Model | Pettitt A | β | 2015 | β |
| Neurodevelopment and phenotype-modulating functions of S100B protein: a pilot study. | Davydov DM et al. | β | 2015 | β |
| No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects. | GonzΓ‘lez-Giraldo Y et al. | β | 2015 | β |
| Population frequencies of the Triallelic 5HTTLPR in six Ethnicially diverse samples from North America, Southeast Asia, and Africa. | Haberstick BC et al. | β | 2015 | β |
| Serotonin transporter availability may moderate the association between perceiving stress and depressive tendencies - A SPECT with 5-HTTLPR genotyping study. | Lin SH et al. | β | 2015 | β |
| Serotonin transporter gene polymorphism (5-HTTLPR) influences trait anxiety by modulating the functional connectivity between the amygdala and insula in Han Chinese males. | Zhang L et al. | β | 2015 | β |
| Serotonin transporter polymorphism (5-HTTLPR) in Croatian population. | Culej J et al. | β | 2015 | β |
| Short alleles, bigger smiles? The effect of 5-HTTLPR on positive emotional expressions. | Haase CM et al. | β | 2015 | β |
| An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. | Sharpley CF et al. | β | 2014 | β |
| Are there meaningful biomarkers of treatment response for depression? | Breitenstein B et al. | β | 2014 | β |
| Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. | Lovallo WR et al. | β | 2014 | β |
| Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder. | Wang TY et al. | β | 2014 | β |
| Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response. | Domschke K et al. | β | 2014 | β |
| Do interviewer and physician health ratings predict mortality?: a comparison with self-rated health. | Todd MA et al. | β | 2013 | β |
| Perceived stress and biological risk: is the link stronger in Russians than in Taiwanese and Americans? | Glei DA et al. | β | 2013 | β |
| Serotonin transporter gene moderates associations between mood, memory and hippocampal volume. | Price JS et al. | β | 2013 | β |
| The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala. | Long H et al. | β | 2013 | β |
| 5-HTTLPR polymorphism impacts task-evoked and resting-state activities of the amygdala in Han Chinese. | Li S et al. | β | 2012 | β |
| Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans. | Peralta-Leal V et al. | β | 2012 | β |
| Association of serotonin transporter gene polymorphism 5-HTTLPR and depressive disorder in a Mexican population. | Peralta-Leal V et al. | β | 2012 | β |
| Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism. | Wang TY et al. | β | 2012 | β |
| Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy. | Porcelli S et al. | β | 2012 | β |
| Relaxation practice and physiologic regulation in a national sample of older Taiwanese. | Glei DA et al. | β | 2012 | β |
| Social relationships and inflammatory markers: an analysis of Taiwan and the U.S. | Glei DA et al. | β | 2012 | β |
| Gene-environment interactions in geriatric depression. | Lotrich FE | β | 2011 | β |
| Life stressors and 5-HTTLPR interaction in relation to midpregnancy depressive symptoms among African-American women. | Scheid JM et al. | β | 2011 | β |
| Novelty-seeking DRD4 polymorphisms are associated with human migration distance out-of-Africa after controlling for neutral population gene structure. | Matthews LJ et al. | β | 2011 | β |
| Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. | Uher R et al. | β | 2011 | β |
| Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants. | Avula R et al. | β | 2011 | β |
| The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. | Minelli A et al. | β | 2011 | β |
| The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. | Karg K et al. | β | 2011 | β |
| Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression? | Wankerl M et al. | β | 2010 | β |
| Overview of the genetics of major depressive disorder. | Lohoff FW | β | 2010 | β |
| Serotonin transporter gene polymorphisms and treatment-resistant depression. | Bonvicini C et al. | β | 2010 | β |