Acute locomotor activation produced by ethanol was also investigated (1.0, 1.5 and 2.0 g/kg). We noted that although they had been fully habituated to the testing chambers prior to injection, Lwt/+ mice exhibited a slight but significant increase in locomotor activity in response to saline injection relative to +/+ littermates (P = 0.038, post hoc Tukey test). Wild-type animals exhibited significant activation at all doses tested (P<0.01, post hoc Tukey test) (Figure 5C). In contrast, no locomotor activation in response to ethanol injection was observed in Lwt/+ mice (Figure 5D).
