We have investigated the effect of the exon III VNTR polymorphism and acute subjective and physiological responses to amphetamine in our sample (Lee et al. 2006), and found that individuals with a single copy of the 7-repeat allele experienced more rewarding effects of the drug, with increased scores on the POMS Friendliness, POMS Elation, and heart rate scales at 20 mg and on the DEQ More scale at 10 mg and decreased scores on the ARCI Dysphoria and POMS Anxiety scales at 20 mg when compared to individuals lacking the 7-repeat allele. Therefore, the 7-repeat allele may modulate subjective and physiological responses to acute amphetamine administration.
