Childhood adversity and ADH1B-rs1229984 showed a significant additive interaction effect on Maxdrinks (p-value<0.01). Among participants who experienced childhood adversity, the adjusted mean difference in Maxdrinks between those with the GG genotype and those with the AA/AG genotype was 3.22. Among participants who did not experience childhood adversity, the adjusted mean difference in Maxdrinks by genotype was only 0.80. The interaction contrast [IC] (difference in differences) was 2.42 (Table 2, Figure 1a).
