implicated. In order to see if this was unexpected in the genome, we smoothed the proportion of significant haplotypes across the genome and looked for other regions that matched or exceeded the maximum smoothed value found in ANK3. We found 10 additional regions covering approximately 1.5 Mb or about 0.05% of the genome that exceeded this level of haplotype heterogeneity, indicating that the proportion of haplotypes that are associated with BD at this locus is relatively high, compared to the rest of the genome (Table S3). This provides additional support that the region shows allelic heterogeneity.
