poorly understood. Although preliminary research has suggested possible genetic differences between Blacks and Whites with regard to depression risk and the response to pharmacological treatments of depression (Lotrich et al., 1997; Gelertner et al., 1998; Gelertner et al., 1999; Lotrich et al., 2003; McMahon et al., 2006), the findings are contradictory and difficult to interpret because these studies are few and the sample sizes are relatively small.