Meiotic recombination is one of the most fundamental biological mechanisms to ensure normal embryonic development. Because too few recombination events can result in nondisjunction and aneuploidy, and ectopic exchange can result in chromosomal rearrangements75,76, it is likely that this process is highly regulated77. Recently, the rate of recombination78 and location of recombination79 were shown to be heritable phenotypes in human pedigrees.
